Comparative and combined effectiveness of innovative therapies in cancer: A literature review
Geldof, Tine Rawal, Smita Van Dyck, Walter Huys, Isabelle
Geldof, Tine
Rawal, Smita
Van Dyck, Walter
Huys, Isabelle
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Publication Type
Journal article with impact factor
Editor
Supervisor
Publication Year
2019
Journal
Journal of Comparative Effectiveness Research
Book
Publication Volume
8
Publication Issue
4
Publication Begin page
Publication End page
Publication Number of pages
Collections
Abstract
To achieve therapeutic innovation in oncology, already expensive novel medicines are often concomitantly combined to potentially enhance effectiveness. While this aggravates the pricing problem, comparing effectiveness of novel yet expensive (concomitant) treatments is much needed for healthcare decision-making to deliver effective but affordable treatments. This study reviewed published clinical trials and real-world studies of targeted and immune therapies. In total, 48 studies compared and/or combined multiple novel products on breast, colorectal, lung and melanoma cancers. To a great extent, products evaluated in each study were owned by one manufacturer. However, cross-manufacturer assessments are also needed. Next to costs and intensive market competition, the absence of a regulatory framework enforcing real-world multiproduct studies prevents these from being conducted. Trusted third parties could facilitate such real-world studies, for which appropriate and efficient data access is needed.
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Keywords
Clinical Studies, Combination Studies, Comparative Studies, Immune-oncology, Literature Review, Precision-oncology, Real-world Evidence