• A typology-based decisional framework to support market access and reimbursement decisions for personalised medicines

      Govaerts, Laurenz; Geldof, Tine; Simoens, Steven; Huys, Isabelle (Value in Health. The Journal of the International Society for Pharmacoeconomics and Outcomes Research, 2017)
      New co-development approaches in personalized medicine challenge current decisional frameworks of health-technology access and reimbursement procedures. We aim to conceptualize an efficient typology-based decisional framework which takes into account the development and market access synchronism between therapeutic (Tx) and diagnostic (Dx) components of personalized medicines.
    • A typology-based decisional framework to support market access and reimbursement decisions for personalized medicines

      Govaerts, Laurenz; Geldof, Tine; Simoens, Steven; Huys, Isabelle; Van Dyck, Walter (2017)
    • Access decision-making in the Belgian Commission for reimbursement of medicines 2010-2017: Investigating the readiness for value-based pricing

      Van Dyck, Walter; Schoonaert, Lies; Geldof, Tine; Govaerts, Laurenz (2018)
      To balance the societal need for affordability of medicines with the industrial need for sustained innovation, the present pharmaceutical technology supply-driven system needs to become a societal demand-driven system. Value-based pricing is considered to be a key component of such a system, next to the conditional dialogue between payer and industry we proposed in previous work (Van Dyck, De Grève et al. 2016) in which it should be embedded. To find out how far Belgian pharmaceutical healthcare-related decision-making has evolved within this paradigm, we empirically investigated the access and reimbursement decision-making of the Belgian Commission for Reimbursement of Medicines (CRM) for the period 2010 – 2017. We combined this investigation with previous work in a meta-analysis in order to have the most complete picture possible of the present factors influencing decision-making in the Belgian system.
    • Acting with foresight in times of budget austerity

      Van Dyck, Walter; Schoonaert, Lies (2019)
      Horizon scanning is acknowledged to be one of the key components of a demand-driven healthcare system. We propose it to be a dynamic collaborative process driven by national unmet need matched with continued insight into the innovative pharmaceutical industry medicinal pipeline. Summer 2019 an international agreement was reached between payers to set up and commission an international horizon scanning initiative (IHSI), which is the international front-end of such a system. In this Policy Paper we propose a two-stage structure and organisation of the back-end national part of the horizon scanning process still to be implemented. This will lead to healthcare budgets managed with better foresight, a necessity in the face of breakthrough, some potentially curing therapies coming at a high cost. Taking the Belgian national component of the proposed horizon scanning system to implementation will require a pilot to be carried out. This to test the internal and external validity of the proposed design.
    • An examination of the influence of ICT on patient co-creation in healthcare service delivery at the micro level

      Osei-Frimpong, Kofi; Wilson, Alan; Lemke, Fred (2016)
      This study provides an empirical perspective of the influence of online health information search on patient co-creation in healthcare service delivery at the micro level. The study primarily sheds light on the influence of information seeking on the clinical encounter process and how this cumulatively impacts on the expected service outcomes. The following research questions are addressed: 1. How do patients search for information and what motivates them to seek health related information? 2. What impact does online information seeking have on patients’ engagement in healthcare clinical encounters? 3. How is co-creation modeled in healthcare to ascertain the cumulative effects of ICT on the expected outcomes at the micro level?
    • Impact of uncertainty in times of network formation

      Cardoen, Brecht; Peeters, Carine; Van Dyck, Walter; Schoonaert, Lies (2017)
    • Implications of switching from a to-day to a to-week patient scheduling strategy, an application at the UZ Leuven

      Samudra, Michael; Demeulemeester, Erik; Cardoen, Brecht (2013)
      In most hospitals there are some patients who receive surgery later than required. As their health condition can potentially quickly worsen, they are exposed to a health risk. In order to improve the current situation, the lateness of patients has to be, firstly, quantified and, secondly, the responsible mechanism has to be understood, namely the patient scheduling process. We analyzed the percentage of patients being served late in Belgium’s largest hospital, the UZ Leuven. At the hospital, an elective patient is associated with one of five due time intervals within which the patient has to be served. We analyzed the lateness of patients across disciplines using all data from 2012 and 22 ORs. We tried to understand many of the different aspects related to the scheduling process, which knowledge we then included into a simulation model. We investigated from the data: patient arrival patterns, the relation between estimated and realized surgery durations, rescheduling mechanisms and the allocation patterns of emergencies. We also used the model to investigate the effects of switching from the current scheduling practice of assigning surgeries directly to slots (OR and day) to a two-step procedure, where patients are scheduled to a surgery week first and only in a second step to slots. Our results suggest that in case of the two-step procedure it is very important to allow patients with shorter due times to break into the already fixed weekly schedule. Additionally, it is important that in the second step of the scheduling procedure, in the within week scheduling, the due time is considered. We conclude that improving patient scheduling can help to decrease the amount of patients served too late. As a next step, we try to develop a sound scheduling schema, which allows to further decrease the number of patients served to late.
    • Managing critical resources through an improved surgery scheduling proces

      Demeulemeester, Erik; Beliën, Jeroen; Cardoen, Brecht (2010)
    • Oncology horizon scanning project

      Van Dyck, Walter; Geldof, Tine (2015)
      A very strong pipeline of oncology precision medicines will become accessible to patients now and in the immediate future. Over the next five years a range of innovative precision medicines or targeted therapies will reach the market, followed by new immunotherapies. Also, taking as a basis this raising targeted therapeutics pipeline we showed an equivalently raising diagnostics pipeline, not only used for properly targeting precision medicines, but also more and more for screening, monitoring and treatment optimization. In this study we investigate whether Belgium is ready to make this disruptive medical technology available to its citizens.
    • Patient co-creation activities in healthcare service delivery at the Micro level: The influence of online access to healthcare information

      Osei-Frimpong, K.; Wilson, A.; Lemke, Fred (Technological forecasting and social change, 2018)
      The healthcare sector has undergone a number of transformations in recent years, partly due to recent advances in technology. This triggered our study to examine patients' desire to seek health information largely driven by increased access via the Internet and the cumulative impacts on value co-creation. We employed a sequential exploratory design involving a phenomenological approach in the qualitative phase, followed by a quantitative survey design to further our understanding of the influence of technology in co-creating value in healthcare at the micro level. Advances in technology have empowered patients to be informed, which enabled them to play an active role in clinical encounters with the doctor. The findings suggest pre-encounter information search impacts positively on improved service engagement and commitment to compliance with medical instructions. It does this by shaping the nature of interactions, enhancing provider-patient orientation, and increasing their involvement in a shared decision-making process. From a theoretical perspective, our study integrates multiple research perspectives (e.g., access to information, online information seeking and knowledge creation, healthcare consultation models, etc.) and extends research on patient integration, participation, and co-creation of value. The conceptualization of value co-creation activities in this study suggests a need for service providers to adopt delivery approaches that would effectively integrate patient resources to co-create value.
    • Personalized medicine: Time to invest more in our health

      Van Dyck, Walter; Cardoen, Brecht; Neels, Leo (The Clinical Services Journal, 2015)
      Healthcare is on the verge of a revolution, especially as miniaturised digital technology, more powerful computing and an attitude change converse and reshape the way we deal with health issues.
    • Smart metering interoperability issues and solutions: Taking inspiration from other ecosystems and sectors

      Reif, Valerie; Meeus, Leonardo (Utilities Policy, 2022)
      Interoperability in the context of smart electricity metering is high on the European policy agenda, but its essence has been challenging to capture. This paper looks at experiences in other ecosystems (electromobility and buildings), in other sectors (healthcare and public administration), and at the national level in the Netherlands and the UK. We show that the definition of interoperability depends on the context, that there are common solutions to different issues across sectors and that cross-sectoral factors must be increasingly considered. We recommend adopting a broader view in smart metering beyond the interoperability of devices, considering solutions that have worked in other sectors and exploiting synergies across sectors. Our analysis of experiences provides a comparison that can help move the debate at the EU level forward.