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dc.contributor.authorDefourny, Jean
dc.contributor.authorMateo Sanchez, Susana
dc.contributor.authorSchoonaert, Lies
dc.contributor.authorRobberecht, Wim
dc.contributor.authorDavy, Alice
dc.date.accessioned2017-12-02T15:00:09Z
dc.date.available2017-12-02T15:00:09Z
dc.date.issued2015
dc.identifier.doi10.1038/ncomms8017
dc.identifier.urihttp://hdl.handle.net/20.500.12127/5604
dc.description.abstractIn mammals, cochlear sensory hair cells that are responsible for hearing are postmitotic and are not replaced after loss. One of the most promising strategies to regenerate hair cells is to identify and inhibit the factors preventing the conversion of adjacent non-sensory supporting cells into hair cells. Here we demonstrate that mammalian hair cells can be directly generated from supporting cells by inhibition of ephrin-B2 signalling. Using either ephrin-B2 conditional knockout mice, shRNA-mediated gene silencing or soluble inhibitors, we found that downregulation of ephrin-B2 signalling at embryonic stages results in supporting cell translocation into hair cell layers and subsequent switch in cell identity from supporting cell to hair cell fate. As transdifferentiation is here a result of displacement across boundary, this original finding presents the interest that newly generated hair cells directly integrate either hair cell layer, then would be likely more rapidly able to fit into functional circuitry.
dc.language.isoen
dc.subjectOperations & Supply Chain Management
dc.titleCochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling
dc.identifier.journalNature Communications
vlerick.knowledgedomainOperations & Supply Chain Management
vlerick.typearticleJournal article
dc.identifier.vperid214024
dc.identifier.vperid214021
dc.identifier.vperid214022
dc.identifier.vperid214023
dc.identifier.vperid211254
dc.identifier.vpubid6898


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