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dc.contributor.authorGeldof, Tine*
dc.contributor.authorRawal, Smita*
dc.contributor.authorVan Dyck, Walter*
dc.contributor.authorHuys, Isabelle*
dc.contributor.authorGeldof, Tine
dc.contributor.authorRawal, Smita
dc.contributor.authorVan Dyck, Walter
dc.contributor.authorHuys, Isabelle
dc.date.accessioned2019-02-12T14:38:35Z
dc.date.available2019-02-12T14:38:35Z
dc.date.issued2019
dc.identifier.issn2042-6305
dc.identifier.doi10.2217/cer-2018-0131
dc.identifier.urihttp://hdl.handle.net/20.500.12127/6140
dc.description.abstractTo achieve therapeutic innovation in oncology, already expensive novel medicines are often concomitantly combined to potentially enhance effectiveness. While this aggravates the pricing problem, comparing effectiveness of novel yet expensive (concomitant) treatments is much needed for healthcare decision-making to deliver effective but affordable treatments. This study reviewed published clinical trials and real-world studies of targeted and immune therapies. In total, 48 studies compared and/or combined multiple novel products on breast, colorectal, lung and melanoma cancers. To a great extent, products evaluated in each study were owned by one manufacturer. However, cross-manufacturer assessments are also needed. Next to costs and intensive market competition, the absence of a regulatory framework enforcing real-world multiproduct studies prevents these from being conducted. Trusted third parties could facilitate such real-world studies, for which appropriate and efficient data access is needed.
dc.language.isoen
dc.publisherFuture Medicine Ltd
dc.subjectClinical Studies
dc.subjectCombination Studies
dc.subjectComparative Studies
dc.subjectImmune-oncology
dc.subjectLiterature Review
dc.subjectPrecision-oncology
dc.subjectReal-world Evidence
dc.titleComparative and combined effectiveness of innovative therapies in cancer: A literature review
dc.identifier.journalJournal of Comparative Effectiveness Research
dc.source.volume8
dc.source.issue4
dc.contributor.departmentKU Leuven
dc.contributor.departmentUniversity of Georgia, Athens, United States
dc.identifier.eissn2042-6313
vlerick.knowledgedomainOperations & Supply Chain Management
vlerick.knowledgedomainSpecial Industries : Healthcare Management
vlerick.typearticleJournal article with impact factor
vlerick.vlerickdepartmentTOM
dc.identifier.vperid176581
dc.identifier.vperid31183


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