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    Comparative and combined effectiveness of innovative therapies in cancer: A literature review (Published Online)

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    Publication type
    Article in academic journal
    Author
    Geldof, Tine
    Rawal, Smita
    Van Dyck, Walter
    Huys, Isabelle
    Publication Year
    2019
    Journal
    Journal of Comparative Effectiveness Research
    
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    Abstract
    To achieve therapeutic innovation in oncology, already expensive novel medicines are often concomitantly combined to potentially enhance effectiveness. While this aggravates the pricing problem, comparing effectiveness of novel yet expensive (concomitant) treatments is much needed for healthcare decision-making to deliver effective but affordable treatments. This study reviewed published clinical trials and real-world studies of targeted and immune therapies. In total, 48 studies compared and/or combined multiple novel products on breast, colorectal, lung and melanoma cancers. To a great extent, products evaluated in each study were owned by one manufacturer. However, cross-manufacturer assessments are also needed. Next to costs and intensive market competition, the absence of a regulatory framework enforcing real-world multiproduct studies prevents these from being conducted. Trusted third parties could facilitate such real-world studies, for which appropriate and efficient data access is needed.
    Keyword
    Clinical Studies, Combination Studies, Comparative Studies, Immune-oncology, Literature Review, Precision-oncology, Real-world Evidence
    Knowledge Domain/Industry
    Operations & Supply Chain Management
    Special Industries : Healthcare Management
    DOI
    10.2217/cer-2018-0131
    URI
    http://hdl.handle.net/20.500.12127/6140
    ae974a485f413a2113503eed53cd6c53
    10.2217/cer-2018-0131
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